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Pioneers conquer core histones at the chromatin frontier - Nature Structural & Molecular Biology

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Pioneers conquer core histones at the chromatin frontier - Nature Structural & Molecular Biology

Pioneer transcription factors access gene regulatory sites embedded within chromatin. They drive gene expression programs vital for cell fate decisions and cellular reprogramming, but how they engage nucleosomal sites at the molecular level is unclear. New results show that they engage histones and collaborate to overcome the nucleosome barrier.

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Pioneers conquer core histones at the chromatin frontier - Nature Structural & Molecular Biology

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Pioneers conquer core histones at the chromatin frontier - Nature Structural & Molecular Biology

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