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Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity - Nature Immunology

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Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity - Nature Immunology

In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how intrinsically disordered regions affect chromatin and control cell fate is unclear. Here, we report that deletion of an intrinsically disordered region of the pioneer factor TCF-1 (termed L1) leads to an early developmental block in T cells.

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Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity - Nature Immunology

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Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity - Nature Immunology

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