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Lipid saturation controls nuclear envelope function - Nature Cell Biology

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Lipid saturation controls nuclear envelope function - Nature Cell Biology

The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl chain unsaturation as essential for NE and nuclear pore complex (NPC) architecture and function. Increased lipid saturation rigidifies the NE and the endoplasmic reticulum into planar, polygonal membranes, which are fracture prone.

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Lipid saturation controls nuclear envelope function - Nature Cell Biology

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Lipid saturation controls nuclear envelope function - Nature Cell Biology

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