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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans - Nature

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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans - Nature

Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required for oxidative phosphorylation1. Heteroplasmy refers to the presence of a mixture of mtDNA alleles in an individual and has been associated with disease and ageing. Mechanisms underlying common variation in human heteroplasmy, and the influence of the nuclear genome on this variation, remain insufficiently explored.

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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans - Nature

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Nuclear genetic control of mtDNA copy number and heteroplasmy in humans - Nature

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