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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease - Nature Medicine

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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease - Nature Medicine

Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of Aβ plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown.

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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease - Nature Medicine

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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease - Nature Medicine

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