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9 months ago

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Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis - Nature Reviews Rheumatology

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Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis - Nature Reviews Rheumatology

Sleep has a homeostatic role in the regulation of the immune system and serves to constrain activation of inflammatory signalling and expression of cellular inflammation. In patients with rheumatoid arthritis (RA), a misaligned inflammatory profile induces a dysregulation of sleep–wake activity, which leads to excessive inflammation and the induction of increased sensitivity to pain.

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Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis - Nature Reviews Rheumatology

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Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis - Nature Reviews Rheumatology

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