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10 months ago

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Endosome positioning coordinates spatially selective GPCR signaling - Nature Chemical Biology

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Endosome positioning coordinates spatially selective GPCR signaling - Nature Chemical Biology

G-protein-coupled receptors (GPCRs) can initiate unique functional responses depending on the subcellular site of activation. Efforts to uncover the mechanistic basis of compartmentalized GPCR signaling have concentrated on the biochemical aspect of this regulation. Here we assess the biophysical positioning of receptor-containing endosomes as an alternative salient mechanism.

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Endosome positioning coordinates spatially selective GPCR signaling - Nature Chemical Biology

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Endosome positioning coordinates spatially selective GPCR signaling - Nature Chemical Biology

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