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Hijacking a P450 for ketone synthesis - Nature Catalysis

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Hijacking a P450 for ketone synthesis - Nature Catalysis

Directed evolution has been extensively used to develop enzymes with enhanced properties, but there are limited examples of diverting key intermediates in catalytic cycles down alternative pathways. Now, a cytochrome P450 variant with promiscuous catalytic activity has been repurposed into a ketone synthase for the catalytic aerobic oxidation of internal alkenes to ketones.

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Hijacking a P450 for ketone synthesis - Nature Catalysis

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Hijacking a P450 for ketone synthesis - Nature Catalysis

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