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Apoptotic contraction drives target cell release by cytotoxic T cells - Nature Immunology

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Apoptotic contraction drives target cell release by cytotoxic T cells - Nature Immunology

Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells1. To kill, CTLs form a specialized cytotoxic immune synapse (IS) with a target of interest and then release toxic perforin and granzymes into the interface to elicit programmed cell death2–5. The IS then dissolves, enabling CTLs to search for additional prey and professional phagocytes to clear the corpse6.

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Apoptotic contraction drives target cell release by cytotoxic T cells - Nature Immunology

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Apoptotic contraction drives target cell release by cytotoxic T cells - Nature Immunology

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