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N6-adenosine methylation controls the translation of insulin mRNA - Nature Structural & Molecular Biology

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N6-adenosine methylation controls the translation of insulin mRNA - Nature Structural & Molecular Biology

Control of insulin mRNA translation is crucial for energy homeostasis, but the mechanisms remain largely unknown. We discovered that insulin mRNAs across invertebrates, vertebrates and mammals feature the modified base N6-methyladenosine (m6A). In flies, this RNA modification enhances insulin mRNA translation by promoting the association of the transcript with polysomes.

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N6-adenosine methylation controls the translation of insulin mRNA - Nature Structural & Molecular Biology

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N6-adenosine methylation controls the translation of insulin mRNA - Nature Structural & Molecular Biology

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