Article
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities - Nature Structural & Molecular Biology
Rating:
0.0
Views:
122
Likes:
1
Library:
1
Transcriptional co-regulators have been widely pursued as targets for disrupting oncogenic gene regulatory programs. However, many proteins in this target class are universally essential for cell survival, which limits their therapeutic window. Here we unveil a genetic interaction between histone deacetylase 1 (HDAC1) and HDAC2, wherein each paralog is synthetically lethal with hemizygous deletion of the other.
Rate This Post
Rate The Educational Value
Rate The Ease of Understanding and Presentation
Interesting or Boring? Rate the Entertainment Value