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Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1 - Nature Structural & Molecular Biology

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Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1 - Nature Structural & Molecular Biology

In mammals, the kidney plays an essential role in maintaining blood homeostasis through the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion transporters (OATs) are responsible for the recognition of metabolites and toxins in the nephron and their eventual urinary excretion. Inhibition of OATs is used therapeutically to improve drug efficacy and reduce nephrotoxicity.

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Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1 - Nature Structural & Molecular Biology

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Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1 - Nature Structural & Molecular Biology

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