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Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S - Nature

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Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S - Nature

Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation1–4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacetylates histones H3 and H4 at multiple sites across transcribed regions5–7. Here we solved the cryo-electron microscopy structures of Saccharomyces cerevisiae Rpd3S in its free and H3K36me3 nucleosome-bound states.

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Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S - Nature

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Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S - Nature

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