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Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools - Nature Chemical Biology

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Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools - Nature Chemical Biology

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and stimulate the generation of second messengers such as cyclic adenosine monophosphate (cAMP). A long-standing puzzle is deciphering how GPCRs elicit different physiological responses despite generating similar levels of cAMP. We previously showed that some GPCRs generate cAMP from both the plasma membrane and the Golgi apparatus.

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Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools - Nature Chemical Biology

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Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools - Nature Chemical Biology

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