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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1 - Nature Structural & Molecular Biology

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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1 - Nature Structural & Molecular Biology

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. Phylogenetic analysis reveals several non-arginine residues conserved within, but not across species. The significance of these residues and their post-translational modifications are poorly understood.

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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1 - Nature Structural & Molecular Biology

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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1 - Nature Structural & Molecular Biology

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