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9 months ago

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H3K36 methylation is a reprogramming barrier - Nature Cell Biology

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H3K36 methylation is a reprogramming barrier - Nature Cell Biology

Reprogramming of somatic cells is an inherently inefficient process. A new study has now identified histone H3K36 methylation as a crucial reprogramming barrier that operates downstream of TGFβ signalling. Global inhibition of H3K36 methylation induced PRC2-dependent silencing of mesenchymal genes and dramatically increased reprogramming efficiency.

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H3K36 methylation is a reprogramming barrier - Nature Cell Biology

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H3K36 methylation is a reprogramming barrier - Nature Cell Biology

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