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Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis - Nature
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Retrotransposons are highly enriched in the animal genome1–3. The activation of retrotransposons can rewrite host DNA information and fundamentally impact host biology1–3. Although developmental activation of retrotransposons can offer benefits for the host, such as against virus infection, uncontrolled activation promotes disease or potentially drives ageing1–5.
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