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Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network - Nature Immunology

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Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network - Nature Immunology

Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity maturation against pathogens and vaccines. A key source of antigens for GC B cells are immune complexes (ICs) displayed on follicular dendritic cells (FDCs). Here we show that FDC spatial organization regulates antigen dynamics in the GC. We identify heterogeneity within the FDC network.

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Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network - Nature Immunology

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Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network - Nature Immunology

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