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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2 - Nature Cell Biology

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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2 - Nature Cell Biology

Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating innate sensing and adaptive immune surveillance in myeloid cells. STING is markedly silenced in various human malignancies and acts as a cell-intrinsic tumour suppressor. How STING exerts intrinsic antitumour activity remains unclear.

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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2 - Nature Cell Biology

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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2 - Nature Cell Biology

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