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Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles - Nature Nanotechnology

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Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles - Nature Nanotechnology

Intravenously administered cyclic dinucleotides and other STING agonists are hampered by low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of cyclic dinucleotides to poly(β-amino ester) nanoparticles through a cathepsin-sensitive linker.

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Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles - Nature Nanotechnology

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Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles - Nature Nanotechnology

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