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Multi-faceted immunoglobulin M meets its elusive receptor - Nature Structural & Molecular Biology
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Immunoglobulin M (IgM) is the most ancient antibody class and key mediator of the primary immune response. New structures reveal how it binds to its only class-specific receptor (FcμR) and offer a tantalizing clue to the role of FcμR in the IgM B cell receptor.
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