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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain - Nature Nanotechnology
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Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood–brain barrier in non-human primates.
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