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Dense 4D nanoscale reconstruction of living brain tissue - Nature Methods

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Dense 4D nanoscale reconstruction of living brain tissue - Nature Methods

Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics and structure–function relationships of the brain's complex and dense information processing network; however, this has been hindered by insufficient 3D resolution, inadequate signal-to-noise ratio and prohibitive light burden in optical imaging, whereas electron microscopy is inherently static.

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Dense 4D nanoscale reconstruction of living brain tissue - Nature Methods

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Dense 4D nanoscale reconstruction of living brain tissue - Nature Methods

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