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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses - Nature Immunology

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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses - Nature Immunology

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. However, the origin and relationship of tDCs to other DC subsets has been unclear. Here we show that tDCs are distinct from other well-characterized DCs and conventional DC precursors (pre-cDCs). We demonstrate that tDCs originate from bone marrow progenitors shared with plasmacytoid DCs (pDCs).

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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses - Nature Immunology

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Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses - Nature Immunology

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