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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability - Nature Cell Biology

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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability - Nature Cell Biology

Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood. Here we discover a checkpoint-regulated cascade of chromatin signalling that activates the histone methyltransferase EHMT2/G9a to catalyse heterochromatin assembly at stressed replication forks.

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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability - Nature Cell Biology

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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability - Nature Cell Biology

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