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An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity - Nature Chemical Biology

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An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity - Nature Chemical Biology

Compact CRISPR-Cas systems offer versatile treatment options for genetic disorders, but their application is often limited by modest gene-editing activity. Here we present enAsCas12f, an engineered RNA-guided DNA endonuclease up to 11.3-fold more potent than its parent protein, AsCas12f, and one-third of the size of SpCas9.

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An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity - Nature Chemical Biology

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An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity - Nature Chemical Biology

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