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A bridged backbone strategy enables collective synthesis of strychnan alkaloids - Nature Chemistry

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A bridged backbone strategy enables collective synthesis of strychnan alkaloids - Nature Chemistry

Bridged frameworks are of high chemical and biological significance, being ubiquitous in pharmaceutical molecules and natural products. Specific structures are usually preformed to build these rigid segments at the middle or late stage in the synthesis of polycyclic molecules, resulting in decreased synthetic efficiency and target-specific syntheses.

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A bridged backbone strategy enables collective synthesis of strychnan alkaloids - Nature Chemistry

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A bridged backbone strategy enables collective synthesis of strychnan alkaloids - Nature Chemistry

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