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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells - Nature Biomedical Engineering

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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells - Nature Biomedical Engineering

Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma, sepsis or another serious insult, which increases the risk of opportunistic infections, morbidity and mortality. Here, we show that in cultured primary human monocytes, interleukin-4 (IL4) inhibits acute inflammation, while simultaneously inducing a long-lasting innate immune memory named trained immunity.

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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells - Nature Biomedical Engineering

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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells - Nature Biomedical Engineering

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