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Relaxed targeting rules help PIWI proteins silence transposons - Nature

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Relaxed targeting rules help PIWI proteins silence transposons - Nature

In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make a second clade of Argonaute proteins: PIWI proteins. PIWI proteins use PIWI-interacting RNAs (piRNAs) to repress complementary transposon transcripts1,2. In theory, transposons could evade silencing through target site mutations that reduce piRNA complementarity.

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Relaxed targeting rules help PIWI proteins silence transposons - Nature

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Relaxed targeting rules help PIWI proteins silence transposons - Nature

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