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Local immune activation shapes systemic HIV reservoirs - Nature Medicine
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In a person living with with human immunodeficiency virus (HIV), the recruitment of CD4+ T cells that recognize a co-pathogen in the central nervous system (CNS) resulted in localized inflammation and sparked HIV replication in the presence of suboptimal CNS anti-retroviral levels, leading to systemic virological failure. This case highlights the importance of considering inflammation and co-infection in HIV remission strategies.
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