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Spatiotemporal dynamics of focal adhesion kinase - Nature Chemical Biology

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Spatiotemporal dynamics of focal adhesion kinase - Nature Chemical Biology

We designed FAK-SPARK, a fluorescent reporter of focal adhesion kinase (FAK) activity based on phase separation. FAK-SPARK revealed polarized FAK activity within single focal adhesions in the leading edges of migrating cells. By combining FAK-SPARK with DNA tension probes, we showed that FAK activity is proportional to the tension strength.

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Spatiotemporal dynamics of focal adhesion kinase - Nature Chemical Biology

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Spatiotemporal dynamics of focal adhesion kinase - Nature Chemical Biology

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