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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron - Nature Chemical Biology

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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron - Nature Chemical Biology

Serine hydrolases have important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to the Bacteroidetes phylum. Two are predicted homologs of the human dipeptidyl peptidase 4 (hDPP4), a key enzyme that regulates insulin signaling.

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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron - Nature Chemical Biology

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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron - Nature Chemical Biology

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