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Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space - Nature Chemistry

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Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space - Nature Chemistry

Challenges in the synthesis of heparan sulfate (HS) glycosaminoglycans have limited access to defined HS oligosaccharides bearing a diverse array of sulfation sequences. A concise, divergent synthetic approach now provides a library of 64 HS tetrasaccharides displaying a comprehensive set of sulfation sequences, offering insight into the elusive sulfation code of glycosaminoglycans.

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Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space - Nature Chemistry

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Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space - Nature Chemistry

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