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The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure - Nature Immunology

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The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure - Nature Immunology

Immune checkpoint blockade (ICB) targeting PD-1 and CTLA-4 has revolutionized cancer treatment. However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve durable responses. G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored in immuno-oncology.

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The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure - Nature Immunology

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The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure - Nature Immunology

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