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11 months ago

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LDLs take a shortcut to mitochondria - Nature Cell Biology

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LDLs take a shortcut to mitochondria - Nature Cell Biology

Receptor-mediated endocytosis delivers low-density lipoproteins (LDLs) to late endosomes, from where cholesterol is trafficked to mitochondria. Zhou et al. report that LDL-containing endosomes fuse with mitochondria, supplying cholesterol for steroid biosynthesis and enabling mitochondrial degradation of the LDL receptor.

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LDLs take a shortcut to mitochondria - Nature Cell Biology

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LDLs take a shortcut to mitochondria - Nature Cell Biology

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