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Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology

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Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology

The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is internalized into cells through LDL receptor (LDLR)-mediated endocytosis. The LDLR protein is highly expressed in the steroidogenic organs and LDL cholesterol is an important source for steroidogenesis. Cholesterol must be transported into the mitochondria, where steroid hormone biosynthesis initiates. However, how LDL cholesterol is conveyed to the mitochondria is poorly defined.

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Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology

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Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis - Nature Cell Biology

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