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Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation - Nature Metabolism

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Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation - Nature Metabolism

Drugs can be modified or degraded by the gut microbiota, which needs to be considered in personalized therapy. The clinical efficacy of the antidiabetic drug acarbose, an inhibitor of α-glucosidase, varies greatly among individuals for reasons that are largely unknown. Here we identify in the human gut acarbose-degrading bacteria, termed Klebsiella grimontii TD1, whose presence is associated with acarbose resistance in patients.

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Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation - Nature Metabolism

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Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation - Nature Metabolism

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