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11 months ago

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Aggregation of big tau disrupts microtubules and causes diastolic dysfunction - Nature Reviews Cardiology

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Aggregation of big tau disrupts microtubules and causes diastolic dysfunction - Nature Reviews Cardiology

Hyperphosphorylation of tau in the heart reduces the tyrosination of microtubules, leading to myocardial stiffness and heart failure. This novel mechanism of diastolic dysfunction parallels the aggregation of tau in the brain that leads to Alzheimer disease and might be amenable to treatment using monoclonal antibodies against tau.

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Aggregation of big tau disrupts microtubules and causes diastolic dysfunction - Nature Reviews Cardiology

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Aggregation of big tau disrupts microtubules and causes diastolic dysfunction - Nature Reviews Cardiology

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