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11 months ago

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Transcriptional states do not always predict vascular function and pathology - Nature Cardiovascular Research

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Transcriptional states do not always predict vascular function and pathology - Nature Cardiovascular Research

Targeting the Notch ligand DLL4 in adult liver vessels induced transcriptional states associated with endothelial cell (EC) proliferation and sprouting. However, genetic and pharmacological inhibition of these angiogenic cell states did not prevent an abnormal vasculature and pathology in the liver, suggesting that transcriptional states do not always inform on the vascular phenotype and related pathophysiology.

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Transcriptional states do not always predict vascular function and pathology - Nature Cardiovascular Research

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Transcriptional states do not always predict vascular function and pathology - Nature Cardiovascular Research

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