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Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration - npj Regenerative Medicine

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Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration - npj Regenerative Medicine

Myocardial Brg1 is essential for heart regeneration in zebrafish, but it remains unknown whether and how endothelial Brg1 plays a role in heart regeneration. Here, we found that both brg1 mRNA and protein were induced in cardiac endothelial cells after ventricular resection and endothelium-specific overexpression of dominant-negative Xenopus Brg1 (dn-xbrg1) inhibited myocardial proliferation and heart regeneration and increased cardiac fibrosis.

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Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration - npj Regenerative Medicine

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Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration - npj Regenerative Medicine

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