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11 months ago

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p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer - Cell Death & Differentiation

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p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer - Cell Death & Differentiation

Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical suppressor of inflammation and oncogenic KRASG12D-driven PC tumorigenesis. iASPP suppresses PC onset driven by KRASG12D alone or KRASG12D in combination with mutant p53R172H.

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pancreatic cancer cell inflammation p53 inhibitor suppressor cell biology biology microbiology

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p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer - Cell Death & Differentiation

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p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer - Cell Death & Differentiation

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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