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Accessing three-dimensional molecular diversity through benzylic C–H cross-coupling - Nature Synthesis

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Accessing three-dimensional molecular diversity through benzylic C–H cross-coupling - Nature Synthesis

Pharmaceutical discovery efforts rely on robust synthetic methods that rapidly access diverse molecules. Cross-coupling reactions are the most widely used reactions, but these methods typically form bonds with C(sp2)-hybridized atoms and lead to a prevalence of 'flat' molecules with suboptimal physicochemical and topological properties.

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Accessing three-dimensional molecular diversity through benzylic C–H cross-coupling - Nature Synthesis

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Accessing three-dimensional molecular diversity through benzylic C–H cross-coupling - Nature Synthesis

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