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Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons - Communications Biology

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Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons - Communications Biology

CHD8 encodes chromodomain helicase DNA-binding protein 8 and its mutation is a highly penetrant risk factor for autism spectrum disorder (ASD). CHD8 serves as a key transcriptional regulator on the basis of its chromatin-remodeling activity and thereby controls the proliferation and differentiation of neural progenitor cells. However, the function of CHD8 in postmitotic neurons and the adult brain has remained unclear.

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Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons - Communications Biology

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Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons - Communications Biology

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