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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles - npj Antimicrobials and Resistance

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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles - npj Antimicrobials and Resistance

Antibiotic resistance is a pressing healthcare challenge and is mediated by various mechanisms, including the active export of drugs via multidrug efflux systems, which prevent drug accumulation within the cell. Here, we studied how Salmonella evolved resistance to two key antibiotics, cefotaxime and azithromycin, when grown planktonically or as a biofilm.

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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles - npj Antimicrobials and Resistance

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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles - npj Antimicrobials and Resistance

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