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Label-free nanoscale mapping of intracellular organelle chemistry - Communications Biology

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Label-free nanoscale mapping of intracellular organelle chemistry - Communications Biology

The ability to image cell chemistry at the nanoscale is key for understanding cell biology, but many optical microscopies are restricted by the ~(200–250)nm diffraction limit. Electron microscopy and super-resolution fluorescence techniques beat this limit, but rely on staining and specialised labelling to generate image contrast. It is challenging, therefore, to obtain information about the functional chemistry of intracellular components.

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Label-free nanoscale mapping of intracellular organelle chemistry - Communications Biology

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Label-free nanoscale mapping of intracellular organelle chemistry - Communications Biology

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