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Engineered tRNAs suppress nonsense mutations in cells and in vivo - Nature

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Engineered tRNAs suppress nonsense mutations in cells and in vivo - Nature

Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic diseases1. Nonsense mutations convert a sense codon that is decoded by tRNA into a premature termination codon (PTC), resulting in an abrupt termination of translation. One strategy to suppress nonsense mutations is to use natural tRNAs with altered anticodons to base-pair to the newly emerged PTC and promote translation2–7.

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Engineered tRNAs suppress nonsense mutations in cells and in vivo - Nature

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Engineered tRNAs suppress nonsense mutations in cells and in vivo - Nature

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