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Microbiota metabolites as agonists for the orphan receptor GPRC5A - Nature Chemical Biology

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Microbiota metabolites as agonists for the orphan receptor GPRC5A - Nature Chemical Biology

We used chemical proteomics to identify candidate protein targets of indole metabolites in mammalian cells. We discovered that microbiota-derived and synthetic aromatic monoamines can activate recruitment of β-arrestin to the orphan receptor GPRC5A. Specific microbiota species that express amino acid decarboxylases were found to produce aromatic monoamine agonists for GPRC5A.

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Microbiota metabolites as agonists for the orphan receptor GPRC5A - Nature Chemical Biology

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Microbiota metabolites as agonists for the orphan receptor GPRC5A - Nature Chemical Biology

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