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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease - Nature Medicine

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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease - Nature Medicine

An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence suggests that reactive astrocytes unleash Aβ effects in pathological tau phosphorylation.

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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease - Nature Medicine

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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease - Nature Medicine

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