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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage - Nature Neuroscience

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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage - Nature Neuroscience

Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43, amyotrophic lateral sclerosis and several neurodegenerative diseases, our knowledge of the sequence and structural determinants of its aggregation and neurotoxicity remains incomplete.

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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage - Nature Neuroscience

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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage - Nature Neuroscience

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