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11 months ago

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Captured: the elusive eukaryotic tRNA splicing enzyme - Nature Structural & Molecular Biology

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Captured: the elusive eukaryotic tRNA splicing enzyme - Nature Structural & Molecular Biology

The maturation of transfer RNAs requires the splicing of precursor tRNAs by specific endonucleases. New cryo-electron microscopy studies of the human splicing endonuclease bound to tRNAs shed light on how it cleaves and splices its substrates, explaining the function of eukaryote-specific enzyme subunits and rationalizing disease-associated mutations.

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Captured: the elusive eukaryotic tRNA splicing enzyme - Nature Structural & Molecular Biology

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Captured: the elusive eukaryotic tRNA splicing enzyme - Nature Structural & Molecular Biology

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